{"id":12897,"date":"2024-09-23T16:56:08","date_gmt":"2024-09-23T07:56:08","guid":{"rendered":"https:\/\/www.mecc-nano.com\/?p=12897"},"modified":"2024-09-26T13:12:58","modified_gmt":"2024-09-26T04:12:58","slug":"help-vol-01-how-to-spin-gelatin-effectively","status":"publish","type":"post","link":"https:\/\/mecc-jp.com\/nano\/latest-news\/12897\/","title":{"rendered":"HELP Vol. 02: Let\u2019s Create Samples of Artificial Blood Vessels and Stent Covers for the Exhibition in China!"},"content":{"rendered":"\n

The second edition of \u201cHELP\u201d has begun! For this installment, we are preparing samples of artificial blood vessels and stent covers to be showcased at \u201cMedtec China 2024,\u201d a medical device manufacturing event taking place in China from September 25 (Wednesday) to 27 (Friday).<\/p>\n\n\n\n

2024 Medtec China
18th International Medical Device Design and Manufacturing Technology Exhibition<\/a><\/strong><\/p>\n\n\n\n

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Medtec China Participation Members
(Supporting Japanese, Chinese, and English)<\/figcaption><\/figure>\n<\/div>\n\n\n
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Participants for This Edition of “HELP”<\/strong><\/p>\n<\/div><\/div>\n\n\n\n

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Joining us this time is our new staff member, “Jin,” adding even more power to “HELP”! We look forward to delivering an enhanced experience.<\/p>\n\n\n\n

>>What is “HELP”?<\/a><\/p>\n\n\n\n

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Since the upcoming exhibition is focused on medical devices, I’d like to create tubular nanofibers and have many people see them!<\/p>

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I want to be able to spin tubular nanofibers, too!<\/p>

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Alright, let’s ask spinning expert Nakatsuka-san for help right away!<\/p>

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I’ll join it and learn.<\/p>

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Nakatsuka-san! Please help us!!
We want to learn how to create tubular nanofibers!<\/p>

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Good idea. Tubular nanofibers are ideal for making artificial blood vessels and stent covers in the medical field.<\/p>

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I\u2019d like to practice making samples of artificial blood vessels and stent covers.<\/p>

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What solutions are commonly used?<\/p>

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For artificial blood vessels, PU is often used, and for stent covers, PCL is commonly chosen.<\/p>

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I\u2019ve never spun PCL before, so I\u2019d like to try using PCL.<\/p>

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Me too.<\/p>

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Then how about Jin-san and I work on PU?<\/p>

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Sounds good!<\/p>

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When making tubular samples, let\u2019s use the \u201cMandrel Collector<\/a><\/strong>\u201d from the optional collectors!<\/p>

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Mandrel Collector<\/a><\/strong><\/figcaption><\/figure>\n\n\n\n
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Preparing the Solution for Spinning Tubular Nanofibers<\/h3>\n\n\n\n

We prepared the solution using the ratio that Nakatsuka-san taught us.<\/p>\n\n\n\n

 \u2022 Group A (Ko, Jin)\u2019s solution \u2192 12.5 wt% PU<\/strong><\/p>\n\n\n\n

\u2022Group B (Wang, Masagaki)\u2019s solution \u2192 12 wt% PCL<\/strong><\/p>\n\n\n\n

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How thick are blood vessels?<\/p>

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Blood vessels are classified by size, with those 6mm or larger considered large-diameter, and those under 6mm classified as small-diameter. Incidentally, the production of small-diameter artificial blood vessels is a global challenge.<\/p>

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Can our equipment make small-diameter vessels?<\/p>

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Of course! NANON can create various size of Tubular Nanofibers for blood vessels.<\/p>

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Alright, I\u2019ve decided! Let\u2019s make both large and small ones this time!<\/p>

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< Mandrel Rod Sizes ><\/p>\n\n\n\n

Diameter: 10mm \/ 6mm \/ 2mm<\/p>\n<\/div><\/div>\n\n\n\n

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Let\u2019s try spinning PU (artificial blood vessels)!<\/h3>\n\n\n\n
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Starting with the 6mm rod. You can begin by using the following parameters.<\/p>

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[Parameters]<\/strong>
\u30fbVoltage: 18kV
\u30fbFlow Rate: 1ml\/h
\u30fbSpinning Distance: 150mm
\u30fbNeedle Size: 27G<\/p>\n\n\n\n

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Oh, right! When you spin just PU, the sample won\u2019t come off the rod once it\u2019s done!<\/p>

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What?! Really?! Why is that?<\/p>

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PU adheres tightly to the rod, leaving no gap at all.<\/p>

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What?!So, we just need to create a gap, right?<\/p>

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Exactly! Now, how do we create that gap?<\/p>

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How about spinning a water-soluble solution first? Then, spin PU on top of that. Once the sample is finished, you can soak it in water, and the water-soluble layer will dissolve, creating a gap between the rod and the PU, making it easier to remove\u2026?!<\/p>

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Bingo! That\u2019s correct. So, what water-soluble solution should we use first?<\/p>

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How about PEO?<\/p>

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That\u2019s a great choice! PEO is commonly used.<\/p>

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I see! I learned something new!<\/p>

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Thanks to Nakatsuka-san\u2019s advice, Group A\u2019s experiment progressed smoothly.<\/p>\n\n\n\n

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10\uff4d\uff4d<\/figcaption><\/figure>\n\n\n\n
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10\uff4d\uff4d<\/figcaption><\/figure>\n<\/figure>\n\n\n\n
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2\uff4d\uff4d<\/figcaption><\/figure>\n<\/figure>\n\n\n\n
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10\uff4d\uff4d\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u30006\uff4d\uff4d\u3000\u3000\u3000\u3000\u3000\u30002\uff4d\uff4d<\/figcaption><\/figure>\n<\/figure>\n\n\n\n
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Soaked the PU sample into water like this.<\/p>\n<\/div><\/div>\n\n\n\n

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Let\u2019s Try Spinning PCL (Stent Cover)!<\/h3>\n\n\n\n
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We would like to use a 22G needle.  Let’s see if we can finish spinning in a shorter time with using a thicker needle and increasing the feed rate.<\/p>

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Group B decided to use a 22G needle.<\/p>\n\n\n\n

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Do we need to spin a water-soluble solution first when spinning PCL as well?<\/p>

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No need. PCL will come off instantly if you soak it in ethanol.<\/p>

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Really?! Sounds fun!<\/p>

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10\uff4d\uff4d<\/figcaption><\/figure>\n\n\n\n
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2\uff4d\uff4d<\/figcaption><\/figure>\n<\/figure>\n\n\n\n
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It really came off in just a second! (Though I forgot to capture that important moment\u2026!)<\/p>

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Let\u2019s check the membrane thickness!<\/h3>\n\n\n\n

Since we have the chance, we also measured the membrane thickness.<\/p>\n\n\n\n

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Summary<\/h3>\n\n\n\n

We successfully created tubular nanofiber samples using PU and PCL.<\/p>\n\n\n\n


Group A<\/strong>
To remove PU from the rod, spinning a water-soluble solution first makes it easier to remove, such as PEO
Note: Using ultrasonic cleaning will make the process even faster!<\/p>\n\n\n\n

Group B<\/strong>
1. We successfully spun PCL using a 22G needle with a feed rate of 1.5ml\/h.
 2. Soaking the sample in ethanol allows for easy removal from the rod.<\/p>\n\n\n\n

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Thanks to everyone, we were able to practice creating tubular nanofibers! Thank you very much.<\/p>

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We can confidently show them at the exhibition!<\/p>

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At Medtec China 2024<\/a><\/strong>, where Wang and Gao will participate, we will not only display the samples we created but also conduct a demonstration of nanofiber spinning using our most popular NANON machine. Additionally, we will offer free consultations on spinning, so please come and visit us. Don\u2019t miss seeing the growth of our team members!<\/p>\n\n\n\n

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Tell us! HELP\uff01<\/h3>\n\n\n\n
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We hope you look forward to the next time!<\/p>\n\n\n\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

The second edition of \u201cHELP\u201d has begun! For this installment, we are preparing samples of artificial blood vessels and stent covers to be showcased at \u201cMedtec China 2024,\u201d a medical device manufacturing event taking place in China from September 25 (\u226b more<\/a><\/p>\n","protected":false},"author":4,"featured_media":13249,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-12897","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news"],"_links":{"self":[{"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/posts\/12897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/comments?post=12897"}],"version-history":[{"count":13,"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/posts\/12897\/revisions"}],"predecessor-version":[{"id":13252,"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/posts\/12897\/revisions\/13252"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/media\/13249"}],"wp:attachment":[{"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/media?parent=12897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/categories?post=12897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mecc-jp.com\/nano\/wp-json\/wp\/v2\/tags?post=12897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}