{"version":"1.0","provider_name":"MECC NANOFIBER","provider_url":"https:\/\/mecc-jp.com\/nano","author_name":"mecc-nano","author_url":"https:\/\/mecc-jp.com\/nano\/author\/mecc-nano\/","title":"\u3010Paper\u3011A Macrolide-loaded Nanofiber Insert for Sustainable Intraocular Administration Based on Polycaprolactone and Cellulose Acetate: A Pharmacokinetic Study in the Rabbit Eye - MECC NANOFIBER","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"BrNEr73CEV\"><a href=\"https:\/\/mecc-jp.com\/nano\/technology\/13715\/\">\u3010Paper\u3011A Macrolide-loaded Nanofiber Insert for Sustainable Intraocular Administration Based on Polycaprolactone and Cellulose Acetate: A Pharmacokinetic Study in the Rabbit Eye<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/mecc-jp.com\/nano\/technology\/13715\/embed\/#?secret=BrNEr73CEV\" width=\"600\" height=\"338\" title=\"&#8220;\u3010Paper\u3011A Macrolide-loaded Nanofiber Insert for Sustainable Intraocular Administration Based on Polycaprolactone and Cellulose Acetate: A Pharmacokinetic Study in the Rabbit Eye&#8221; &#8212; MECC NANOFIBER\" data-secret=\"BrNEr73CEV\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/mecc-jp.com\/nano\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","thumbnail_url":"https:\/\/mecc-jp.com\/nano\/wp-content\/uploads\/2024\/06\/paper.png","thumbnail_width":839,"thumbnail_height":758,"description":"\u27a1please click here for the paperA Macrolide-loaded Nanofiber Insert for Sustainable Intraocular Administration Based on Polycaprolactone and Cellulose Acetate: A Pharmacokinetic Study in the Rabbit Eye Bioavailability and DDS Azithromycin (AZM) is a broad-spectrum antibiotic that has anti-inflammatory properties and is used as an ophthalmic agent to treat ocular infections because it acts to cause bacterial conjunctivitis. However, eyedrops have limited bioavailability and require frequent administration. Therefore, in recent years, nano-based novel drug delivery systems that can increase corneal permeation and enhance drug residence lengthening and drug delivery have attracted attention. Bioavailability: an indicator of how well a given drug (formulation) reaches and acts in the systemic circulation. Effectiveness and Prospect of Eye Points by DDS Using Nanofibers Among these methods, the use of nanofibers has characteristics such as high surface area, porous structure, and high drug loading capacity, making it possible to insert nanofibers directly into the conjunctive sac to extend drug residence time at the surface of the conjunctive membrane, and reducing the number of drug dosing, making it one of the most suitable methods for eye-sustaining drug delivery. In practice, a large number of polymers are processed into nanofibers using the electrospinning method. We used cellulose acetate (CA), which is non-toxic, biodegradable, and biocompatible, and polycaprolactone (PCL), a hydrophobic polymer that has received FDA approval for drug delivery, to fabricate nanofibers loaded with AZM and evaluated their efficacy. Since they used to fabricate AZM loaded nanofibers with hydrophilic polymers, they have also evaluated improvements in their pharmaceutical\u226b more"}