{"version":"1.0","provider_name":"MECC NANOFIBER","provider_url":"https:\/\/mecc-jp.com\/nano","author_name":"mecc-nano","author_url":"https:\/\/mecc-jp.com\/nano\/author\/mecc-nano\/","title":"Biocompatible Native Hyaluronan Nanofibers Fabricated via Aqueous PEO-Assisted Electrospinning and Heat-Quench Process - MECC NANOFIBER","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"tOeEGWwtAT\"><a href=\"https:\/\/mecc-jp.com\/nano\/latest-news\/13160\/\">Biocompatible Native Hyaluronan Nanofibers Fabricated via Aqueous PEO-Assisted Electrospinning and Heat-Quench Process<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/mecc-jp.com\/nano\/latest-news\/13160\/embed\/#?secret=tOeEGWwtAT\" width=\"600\" height=\"338\" title=\"&#8220;Biocompatible Native Hyaluronan Nanofibers Fabricated via Aqueous PEO-Assisted Electrospinning and Heat-Quench Process&#8221; &#8212; MECC NANOFIBER\" data-secret=\"tOeEGWwtAT\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/mecc-jp.com\/nano\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","thumbnail_url":"https:\/\/mecc-jp.com\/nano\/wp-content\/uploads\/2024\/06\/paper-3.png","thumbnail_width":839,"thumbnail_height":758,"description":"Professor Fujita and his colleagues at the University of Fukui have published a paper on the preparation of natural hyaluronic acid gel nanofibers. Our NANON and Handy Spinneret were used in this research. \u21d2 Click here to read the paper. Let me briefly introduce the contents ! Hyaluronic acid is used in a wide variety of applications, from cancer treatment to cosmetics. However, the hyaluronic acid used is chemically modified hyaluronic acid, and there are concerns about its safety. Electrospinning hyaluronic acid nanofibers have been studied for various applications, but the use of organic solvents as solvents raises concerns about their application in medical and cosmetic products. The hyaluronic acid gel nanofiber production method presented here uses natural, unmodified hyaluronic acid as the material and water as the solvent, making it possible to produce nanofibers with a high level of safety. Since it is difficult to spin hyaluronic acid alone, this method uses a pH-adjusted solution mixed with polyethylene oxide to improve spinnability. The acidic solution of hyaluronic acid suppresses the divergence of side chains, making it insoluble in water. It has also been confirmed that viscosity decreases under acidic conditions. The solution is adjusted to the optimum pH for spinning by electrospinning, and then heated, quenched, acid-treated, and washed with water to remove PEO, allowing the preparation of hyaluronic acid-only nanofibers. Cell culture on the prepared nanofibers showed selective adhesion to cells with the hyaluronan receptor CD44, suggesting that the nanofibers may be useful as a culture substrate to\u226b more"}